Chloroquine against malaria, cancers and viral diseases
نویسندگان
چکیده
منابع مشابه
Chloroquine resistance in malaria.
Malaria continues to pose a challenge in view of its resurgence and problem of drug resistance. The chloroquine resistance in P. falciparum was first detected in Thailand in 1962(1) and in India in 1973(2). The extent of problem of chloroquine resistance in P. falciparum is increasing every year. Chloroquine resistance in P. falciparum has already been found in twelve different states and Union...
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The malaria parasite's development of resistance to the drug chloroquine is a major threat to world health. A protein likely to be involved in chloroquine resistance has recently been identified; this discovery is important, but raises as many questions as it answers.
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Vaccine approaches to infectious diseases are widely applied and appreciated. Amongst them, vectors based on recombinant viruses have shown great promise and play an important role in the development of new vaccines. Many viruses have been investigated for their ability to express proteins from foreign pathogens and induce specific immunological responses against these antigens in vivo. General...
متن کاملChloroquine resistance in malaria: a deficiency of chloroquine binding.
Chloroquine-(14)C was used to study the processes which concentrate chloroquine in mouse red blood cells infected with chloroquine-sensitive or with chloroquine-resistant Plasmodium berghei. The initial rates of uptake and exchange of chloroquine-(14)C were both too fast to measure, yet large concentration gradients were maintained by the cells. When red blood cells were exposed to 10(-8)M chlo...
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The study was conducted to know the rate of maternally derived antibodies (MDAs) transfer from parents to their offspring and declining the MDAs in their chicks at 0, 7, 14, and 21 days of age against four major poultry viruses like Newcastle disease virus (NDV), Infectious bronchitis virus (IBV), Infectious bursal diseases virus (IBDV), and Avian Reo virus (ARV). The MDAs was studied on Grandp...
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ژورنال
عنوان ژورنال: Drug Discovery Today
سال: 2020
ISSN: 1359-6446
DOI: 10.1016/j.drudis.2020.09.010